11例双硫伦样反应的临床观察

目的探讨双硫伦样反应的临床特点,提高临床医护人员的重视,避免误诊。方法对本院2011年4月至2013年4月收治的11例双硫伦样反应病例进行回顾性分析,总结其发生的原因、临床表现、治疗转归、误诊等。结果①患者发病前均有用药并有饮酒史,药物多为头孢菌素;②临床表现颜面潮红、视物模糊、出汗、口干、头痛、头晕、胸痛、胸闷、心悸、低血压、烦躁、气促、呼吸困难;③对症治疗后多于20⁶0 min临床症状缓解。结论应用可致双硫伦样反应的药物时,治疗过程前后应特别医嘱避免饮酒及应用乙醇制剂。

Clinical Observation of 11 Disulfiram-like Reaction Cases

Objective To discuss the clinical responses of disulfiram-like reaction, raise the awareness of clinical medical staff and avoid misdiagnoses. Method A retrospective analysis of 11 disulfiram-like reaction cases in our hospital from April 2011 to April 2013 will be carried out and the causes, clinical manifestations, treatment effect and misdiagnoses of these cases will be summarized. Results ①All patients had a history of drinking and administering medicine, mostly cephalosporin, prior to the onset of illness. ②Clinical manifestations include facial blushing, blurred vision, perspiration, dry mouth, headache, dizziness, chest pain, chest tightness, palpitation, low blood pressure, fidget, shortness of breath and dyspnea; ③Remission of clinical manifestations appeared after 20-60 minutes＇ symptomatic treatment. Conclusion Doctors should advise patients to forbear from alcohol and other ethanol preparations before and after the treatment when prescribing medicines that may lead to disulfiram-like reaction for them.