Localization of beta-andrenoceptors in the anterior segment of the albino rabbit eye using a fluorescent analog of propranolol.

A fluorescent analog of propranolol, 9-amino-acridin-propranolol (9-AAP), was injected into the carotid arteries of albino rabbits in an attempt to localize β-adrenergic receptors (β-adrenoceptors) in the anterior segment of the eye. 9-AAP fluorescence was noted mainly in the ciliary epithelium, but also in the walls of the episcleral vessels. Only mild fluorescence was noted in the iris sphincter region. It is suggested that these findings are compatible with the distribution of β-receptor sites in the anterior segment of the rabbit eye.