| 垂体后叶素诱发离体蛙心心肌缺血实验模型 |
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| 引用本文： | 刘展,马红萍,彭聿平. 垂体后叶素诱发离体蛙心心肌缺血实验模型[J]. 中国交通医学杂志, 2010, 24(5) |
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| 作者姓名： | 刘展 马红萍 彭聿平 |
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| 作者单位： | 南通大学医学院机能学实验室,江苏,226001 |
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| 基金项目： | 江苏省卫生厅科研项目，南通市应用研究计划 |
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| 摘 要： | 目的:建立一个新的心肌缺血实验模型,探讨垂体后叶素对心肌收缩力和心率的直接影响。方法:采用Straub氏法制备离体蟾蜍心脏标本,用任氏液维持心脏的正常活动,加入1ml含有垂体后叶素0.1U/ml的任氏液,记录心肌收缩力和心率的变化。结果:给予垂体后叶素后,心肌收缩力逐渐下降,心率逐渐减慢。在3min时,收缩力由给药前的(4.33±2.30)克降到(0.62±0.48)克(P<0.01),区域时间由(0.52±0.06)秒延迟到(0.64±0.06)秒(P<0.01)。结论:垂体后叶素可以直接抑制心肌收缩,诱发蟾蜍心脏发生心肌缺血。
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| 关 键 词： | 心肌缺血 心肌收缩力 垂体后叶素 离体蛙心 心率 灌注模型制备 |
The Myocardial Ischemia Models of Isolated Toad Heart Induced by Pituitrin |
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| LIU Zhan,MA Hongping,PENG Yuping. The Myocardial Ischemia Models of Isolated Toad Heart Induced by Pituitrin[J]. Chinese Medical JOurnal of Communications, 2010, 24(5) |
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| Authors: | LIU Zhan MA Hongping PENG Yuping |
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| Abstract: | Objective:To investigate the direct effect of pituitrin on heart contractile in the toad.Methods: Ringers solution was used to maintain the normal action of the heart isolated by the Straub’s method,then the heart was perfused by Ringer’s solution 1 ml containing pituitrin at the concentration of 0.1U/ml,and the myocardiac contractile force and heart rate were recorded separately.Re-sults: It was found that the administrations of pituitrin caused significant decrease of myocardial contractile force and heart rate,com-pared with the controls.Conclusion: The pituitrin has a direct inhibitory effect on the heart and causes heart failure. |
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| Keywords: | myocardial ischemia myocardiac contractile force pituitrin isolated toad heart heart rate perfusion model preparation |
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