| 小檗碱对糖尿病肾病大鼠肾小球系膜细胞 TGF-β1 与Ⅳ型胶原蛋白表达的影响 |
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| 引用本文： | 唐丽琴,吕飞,刘圣,张善堂.小檗碱对糖尿病肾病大鼠肾小球系膜细胞 TGF-β1 与Ⅳ型胶原蛋白表达的影响[J].中国中药杂志,2011,36(24):3494-3497. |
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| 作者姓名： | 唐丽琴 吕飞 刘圣 张善堂 |
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| 作者单位： | 安徽医科大学附属省立医院,安徽合肥,230001 |
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| 基金项目： | 国家自然科学基金项目(81073109);安徽省自然科学基金项目(090413106);安徽省卫生厅医学科研课题(09C219);安徽省科技重点项目(08020303074) |
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| 摘 要： | 目的:探讨小檗碱对糖尿病肾病(DN)大鼠肾病变的保护作用及其机制.方法:以链脲佐菌素(STZ)复制DN大鼠模型,动物分为正常对照组、模型组、小檗碱低、中、高剂量治疗组(50,100,200mg·kg-1 ·d-1)、消渴丸治疗组( XKW,0.8g·kg-1·d-1),8周后检测空腹血糖(FBG)、肾重/体重比(KW/BW)、尿素氮(BUN)、肌酐(Cr)及尿蛋白(Upro)；免疫组织化学检测肾小球系膜细胞转化生长因子β1(TGF-β1)与Ⅳ型胶原(Ⅳ-C)蛋白的表达.结果:ig给药,小檗碱可降低大鼠FBG,KW/BW,BUN,Cr及Upro水平,降低肾小球系膜细胞TGF-与Ⅳ-C蛋白的表达.结论:小檗碱对DN大鼠肾微循环病变具有保护作用,这种作用可能与其抑制肾组织TGF-β1与Ⅳ-C蛋白表达有关.
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| 关 键 词： | 小檗碱 糖尿病肾病 肾小球系膜细胞 转化生长因子β1 Ⅳ型胶原 |
| 收稿时间： | 2011/5/10 0:00:00 |
Effect of berberine on expression of transforming growth factor-beta1 and type IV collagen proteins in mesangial cells of diabetic rats with nephropathy |
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| TANG Liqin,LV Fei,LIU Sheng and ZHANG Shantang.Effect of berberine on expression of transforming growth factor-beta1 and type IV collagen proteins in mesangial cells of diabetic rats with nephropathy[J].China Journal of Chinese Materia Medica,2011,36(24):3494-3497. |
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| Authors: | TANG Liqin LV Fei LIU Sheng and ZHANG Shantang |
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| Institution: | TANG Liqin,LV Fei,LIU Sheng,ZHANG Shantang (Affiliated Provincial Hospital,Anhui Medical University,Hefei 230001,China) |
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| Abstract: | Objective: To explore the effect and mechanism of berberine on diabetic nephropathy in experimental rats.Method: The rat model of diabetic nephropathy was induced by injection of streptozocin(STZ).The rats were divided into 6 groups: control group,model group,3 berberine treatment groups and Xiaoke Wan(XKW) treatment group.The fasting blood glucose(FBG),kidney weight/body weight(KW/BW),blood urea nitrogen(BUN),creatinine(Cr) and urinary protein(Upro)were tested 8 weeks later.The expression of transforming g... |
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