腺苷蛋氨酸对原发性肝癌切除术后肝功能的保护作用

目的探讨腺苷蛋氨酸在原发性肝癌肝切除术后的肝功能的保护作用。方法 40例原发性肝癌行肝切除术患者随机分为两组,试验组术后单一予腺苷蛋氨酸连续应用,对照组予硫普罗宁和还原型谷胱甘肽联合应用,分析比较两组术后第1、3、7天肝功能水平变化。结果除术后第7天,试验组血清TBIL和DBIL明显低于对照组外(P<0.05),其余两组术后第1、3、7天肝功能均无统计学差异。结论腺苷蛋氨酸可在多重机制上起到保护肝功能的作用,适合原发性肝癌患者的围手术期应用。

Protective Effects of S-adenosylmethionine on Liver Function in HCC Patients After Liver Resection

Objective To compare the protective effects of S-adenosylmethionine on liver function in hepatocellular carcinoma （HCC） patients after liver resection.Methods 40 patients undergoing liver resection were divided into experimental group （with S-adenosylmethionine treatment） and control group （with tiopronin and reduced glutathione） randomly.The liver function of ALT,AST,TBIL,DBIL,γ-GT,Alb,Pre-Alb and ALP levels were determined before operation and on days 1,3 and 7 after operation.Results Postoperative TBIL and DBIL levels （on 7 days） in the experimental group were significantly lower than those in the control group（P〈0.05）.The other laboratory tests of liver function after operation were no significant difference.Conclusion As combining apply with tiopronin and reduced glutathione, S-adenosylmethionine was a genuine therapeutic action in the development of postoperative liver function damage restoration on the HCC patients with liver resection.