| 经前舒颗粒对经前期综合征肝气郁证大鼠海马和下丘脑5-HT1A受体表达的影响 |
| |
| 引用本文： | 苏云祥,薛玲. 经前舒颗粒对经前期综合征肝气郁证大鼠海马和下丘脑5-HT1A受体表达的影响[J]. 中国中药杂志, 2011, 36(24): 3498-3501 |
| |
| 作者姓名： | 苏云祥 薛玲 |
| |
| 作者单位： | 山东中医药大学中医药经典理论教育部重点实验室,山东济南,250355 |
| |
| 基金项目： | 国家重点基础研究发展计划(973)项目(2011CB505102);国家自然科学基金重点项目(30930110);国家自然科学基金面上项目(30973688);山东省科技发展计划项目(2010GSF10290) |
| |
| 摘 要： | 目的:研究经前舒颗粒对经前期综合征(premenstrual syndrome,PMS)肝气郁证大鼠海马下丘脑5-羟色胺1A受体( serotonin receptor-1A,5-HT1AR)表达水平的影响.方法:束缚造模法复制PMS肝气郁证大鼠模型,旷场实验评价模型,RTPCR和Western blot方法分别检测大鼠海马和下丘脑5-HT1AR的mRNA及蛋白的表达.结果:经前舒颗粒给药后大鼠旷场实验得分显著升高,海马、下丘脑5-HT1AR mRNA和蛋白表达均显著升高.结论:经前舒颗粒可上调海马和下丘脑中5-HT1AR的表达,这可能是其治疗PMS肝气郁证的作用机制之一.
|
| 关 键 词： | 经前舒颗粒 经前期综合征肝气郁证 5-HT1A受体 |
| 收稿时间： | 2011-02-19 |
Effects of Jingqianshu granule on expression of 5-HT1AR of PMS model rats with Liver-qi stagnation |
| |
| SU Yunxiang and XUE Ling. Effects of Jingqianshu granule on expression of 5-HT1AR of PMS model rats with Liver-qi stagnation[J]. China Journal of Chinese Materia Medica, 2011, 36(24): 3498-3501 |
| |
| Authors: | SU Yunxiang and XUE Ling |
| |
| Affiliation: | Laboratory of Traditional Chinese Medicine Classical Theory, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China. suyunxiangben@hotmail.com |
| |
| Abstract: | Objective: To research the effect of the Jingqianshu granule (JQS)on the expression of serotonin receptor-1A(5-HT1AR)in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression. Method: The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT1AR in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot. Result: After the JQS were administered, the open field scores,the expression of 5-HT1AR mRNA and protein in hippocampus and hypothalamus of rats increased significantly. Conclusion: The JQS granule can up-regulate the expression of 5-HT1AR in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression. |
| |
| Keywords: | Jiangqianshu granule premenstrual syndrome of Liver-qi depression 5-HT1AR |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
