硝苯地平缓释片致嗅觉丧失

1例41岁男性患者,因患高血压病口服硝苯地平缓释片20mg,1次/d。1周后出现嗅觉减退,并逐渐加重。3个月后硝苯地平缓释片剂量改为20mg,2次/d,并给予依那普利和卡维地洛。应用该剂量后第3天嗅觉完全丧失。鼻腔检查发现鼻黏膜充血,双下鼻甲肥大,考虑阻塞性失嗅。停用硝苯地平缓释片后第6天,嗅觉恢复正常。其他降压药继续使用未再出现嗅觉障碍。

Anosmia induced by sustained-release nifedipine tablets

A 41-year-old man ingested one tablet of sustained-release nifedipine 20 mg once daily for hypertension. One week later, the man developed hyposmia, which was aggravated gradually. Three months later, his dosage of nifedipine was changed to 20 mg twice daily. Meanwhile, enalapril and earvedilol were added to his regimen. He developed a complete loss of olfaction on day 3 after receiving the dosage regimen. An examination of nasal cavity showed nasal mucosa congestion and both inferior turbinate hypertrophy. Obstructive anosmia was suspected. His olfaetion returned to normal status on day 6 after discontinuation of sustained- release nifedipine tablets. The other antihypertensive drugs were continued. The olfactory disturbance did not reappear.