口腔正畸改建术联合康复新液治疗错颌畸形患者的疗效及对龈沟液RANKL OPG的影响

目的:研究口腔正畸改建术联合康复新液治疗错颌畸形患者的疗效及对龈沟液RANKL、OPG的影响,并分析临床疗效.方法:选取2015年8月至2016年7月我院收治的78例错颌畸形患者,按照随机数字表法随机分为观察组和对照组,39例每组.对照组使用口腔正畸改建术,观察组在此基础上使用康复新液完成治疗.比较两组患者临床疗效,牙痛程度,龈沟液RANKL、OPG水平,不良反应.结果:观察组总有效率高于对照组92.31%(36/39)比66.67%(26/39)],差异具有统计学意义(P<0.05).观察组的牙痛程度优于对照组,差异具有统计学意义(P<0.05).观察组的龈沟液RANKL水平低于对照组(45.87±4.12)ug/L比(84.86±8.32)ug/L],差异具有统计学意义(P<0.05),OPG水平高于对照组(275.32±21.56)ug/L比(135.98±11.43)ug/L],差异具有统计学意义(P<0.05).观察组和对照组的不良反应率比较差异无统计学意义23.08%(9/39)比28.21%(11/39)](P>0.05).结论:口腔正畸改建术联合康复新液治疗错颌畸形患者,能有效降低龈沟液RANKL浓度,升高OPG浓度,缓解患者疼痛感,临床疗效良好.

Effect of Oral Orthodontic Reconstruction Combined with Kangfuxin Liquid in Treating Wrong Jaw Deformity and Its Effect on RANKL and OPG in Gingival Crevicular Fluid

Objective:To study the effect of oral orthodontic reconstruction combined with Kangfuxin liquid in the treatment of wrong jaw deformity and its effect on RANKL and OPG in gingival crevicular fluid. Methods:78 patients with wrong jaw deformity were choosen in our hospital from August 2015 to July 2016,those patients were divided into observation group and control group according to the order of admission. The control group used oral orthodontic reconstruction,the observation group were given Kangfu new liquid on the basis of control group to complete the treatment. The clinical efficacy, toothache degree, gingival crevicular fluid RANKL,OPG levels and adverse reactions were compared between the two groups. Results:The total ef-fective rate of the observation group was significantly higher than that of the control group 92.31% (36/39) vs 66.67% (26/39)] (P <0.05). The degree of toothache in the observation group was significantly better than that in the control group ( P <0.05) . The level of RANKL in the gingival crevicular fluid was significantly lower than that in the control group (45.87 ± 4.12) ug / L VS(84.86 ± 8.32) ug / L] (P <0.05),and the OPG level was significantly higher than that in the control group (275.32 ± 21.56 ) Ug / L VS(135.98 ± 11.43) ug / L] ( P <0.05) . There was no significant difference in the adverse reaction rate between the ob-servation group and the control group (23.08% (9/39) vs 28.21% (11/39)] (P >0.05). Conclusion:O-ral orthodontic reconstruction combined with Kangfenxin solution can effectively reduce the concentration of RANKL in gingival crevicular fluid, increase the concentration of OPG, alleviate the pain of patients, and have good clinical curative effect.