噻托溴铵联合沙美特罗替卡松对中重度稳定期COPD患者T淋巴细胞炎性因子的影响

目的:探讨研究噻托溴铵联合沙美特罗替卡松对中重度稳定期慢性阻塞性肺疾病(COPD)患者炎性因子、T淋巴细胞的影响.方法:选择2014年2月至2015年2月间于我院呼吸门诊科就诊的中重度稳定期COPD患者80例,将所有患者随机分为两组,其中对照组患者40例行常规吸氧、化痰止咳治疗,观察组患者40例在对照组治疗方法的基础上给予噻托溴铵联合沙美特罗替卡松进行治疗.对两组患者经过2周治疗的临床效果进行统计,并对比治疗前后血清炎性因子白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、血清中T淋巴细胞(CD4+、CD8+、CD4+/CD8+)以及肺功能(FEV1、FVC、FEV1/FVC)水平的变化.结果:观察组患者临床疗效显著优于对照组患者(P<0.05).两组患者治疗后IL-8、TNF-α值同治疗前相比显著降低(P<0.05),观察组患者治疗后IL-8、TNF-α值显著低于对照组患者(P<0.05).两组患者治疗后血清中CD4+和TCD4+/CD8+淋巴细胞较治疗前升高,而CD8+较治疗前下降(P<0.05).观察组患者治疗后血清中CD4+和TCD4+/CD8+淋巴细胞同对照组相比较高,而CD8+相比较低(P<0.05).两组患者经过2周的治疗后肺功能均有改善,且观察组患者改善优于对照组患者(P<0.05).结论:噻托溴铵联合沙美特罗替卡松治疗中重度稳定期COPD患者能够有效的改善患者的肺功能,降低炎性因子水平,增强免疫能力.

Effect of Tiotropium combined with Shah Mette Lo Tikason on T lymphocyte and Inflammatory Factors in patients with Moderate to Severe Stable COPD

Objective:To investigate the effect of tiotropium and Shah Mette Lo Tikason on inflammatoryfactors and T lymphocytes in patients with moderate to severe chronic obstructive pulmonary disease ( COPD) . Methods:Between February 2014 to February 2015 in our hospital respiratory outpatient department visits moderately severe plateau, 80 cases of COPD patients, all patients were randomly divided into two groups, the control group, 40 patients with routine western medicine treatment, the observation group 40 cases in the con-trol group was given on the basis of the treatment. Consult for the occasional bromide combined salmeterol as-signed for treatment. After 2 weeks treatment, and compared before and after treatment serum inflammatory factors interleukin 8 ( IL - 8) tumor necrosis factor alpha] ( TNF alpha) in serum T lymphocytes ( CD4 +CD8 +, CD4 + / CD8 +) and pulmonary function ( FEV1, FVC FEV1 / FVC) level changes. Results:The clinical curative effect of observation group patients was significantly better than the control group patients ( P< 0.05).Two groups after treatment in patients with IL - 8, TNF alpha value significantly reduced compared with before treatment ( P < 0.05) , the observation group after treatment in patients with IL - 8, TNF alpha value was significantly lower than the control group patients (P < 0.05).In the two groups after treatment in patients with serum CD4 +and CD4 + / CD8 +T lymphocytes was increased, the and falling CD8 +than be-fore treatment (P < 0.05).Observation group of patients after treatment serum CD4 + and CD4 + / CD8 + T lymphocytes was higher than the control group, and CD8 +phase is lower (P < 0.05).Two groups of patients after two weeks of lung function were improved after treatment, improve is better than that of control group and observation group patients ( P <0.05) . Conclusion:The seconds for the occasional bromide combined salmet-erol calzone treatment period of COPD patients can effectively improve the patient's lung function, lower levels of inflammatory cytokines, enhance immunity.