| 心肌缺血再灌注损伤的细胞信号转导机制 |
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| 引用本文： | 韩笑,刘建勋.心肌缺血再灌注损伤的细胞信号转导机制[J].中国药理学通报,2004,20(1):4-7. |
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| 作者姓名： | 韩笑 刘建勋 |
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| 作者单位： | 中国中医研究院西苑医院实验研究中心,北京,100091 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 心肌缺血再灌注损伤 (I R损伤 )细胞信号转导机制非常复杂 ,涉及细胞外信号分子、细胞膜上信号接收器、细胞内信号转导通路等多方面变化 ,并在多层次和诸多环节上发生交汇。深入认识心肌I R损伤的细胞信号转导途径 ,有助于阐明其细胞分子机制 ,并为临床防治及药物抗I R损伤作用机制研究提供新的思路
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| 关 键 词： | 缺血 再灌注 信号转导 机制 |
| 文章编号： | 1001-1978(2004)01-0004-04 |
| 修稿时间： | 2003年4月23日 |
Cellular signal transduction mechanisms of myocardial ischemia and reperfusion injury |
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| HAN Xiao,LIU Jian Xun.Cellular signal transduction mechanisms of myocardial ischemia and reperfusion injury[J].Chinese Pharmacological Bulletin,2004,20(1):4-7. |
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| Authors: | HAN Xiao LIU Jian Xun |
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| Abstract: | Cellular signal transduction plays an important role in pathogenesis of myocardial ischemia reperfusion(MIR) injury. During this process, extracellular signal molecules, membrance receptors and intracellular signal paths are involved. There are many cross talkings in signal pathways at many levels. The present article reviews cellular signal transduction mechanisms in MIR. The exploration of MIR's cellular pathogenesis may be beneficial for us to prevent and cure the heart damage in clinic. Furthermore, it may provide a new way of thinking in mechanism research of medicine. |
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| Keywords: | ischemia reperfusion cellular signal transduction pathogenesis |
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