Microbial transformation of azacarbazoles. I. N-methylation of alpha-, beta-, and gamma-carbolines by Kitasatosporia setae strain |
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| Authors: | W Peczyńska-Czoch M Mordarski L Kaczmarek P Nantka-Namirski |
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| Affiliation: | Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroc?aw. |
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| Abstract: | Microbial transformation of selected azacarbazoles, compounds noted for their activity as antitumor agents, conducted with Kitasatosporia setae strain resulted in N-methylation of pyridine nucleus of alpha-, beta- and gamma-carboline molecule. Formed quaternized intermediates were converted in alkaline conditions into corresponding iso-carbolines. The structure of the final products, alpha-, beta- and gamma-iso-carbolines have been established on the basis of spectral data and confirmed by chemical synthesis. |
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