| 石蒜碱2-位羟基构型翻转的探索 |
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| 引用本文： | 赵增,许旭升,孙青龑,陈浩,柳润辉. 石蒜碱2-位羟基构型翻转的探索[J]. 药学实践杂志, 2016, 34(6): 511-515 |
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| 作者姓名： | 赵增 许旭升 孙青龑 陈浩 柳润辉 |
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| 作者单位： | 第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433 |
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| 摘 要： | 目的 对石蒜碱2-位羟基构型翻转的研究，为化合物asiaticumine B的半合成提供基础。方法 通过氧化再还原的方法，探索石蒜碱2-位羟基构型的翻转。结果 完成了石蒜碱2-位羟基构型翻转，总收率49%。结论 探索出一种高效便捷的对石蒜碱2-位羟基构型翻转的方法。
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| 关 键 词： | 石蒜碱 asiaticumine B 构型翻转 |
| 收稿时间： | 2016-04-16 |
| 修稿时间： | 2016-06-21 |
Configuration inversion of C-2-hydroxy in lycorine |
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| ZHAO Zeng,XU Xusheng,SUN Qingyan,CHEN Hao and LIU Runhui. Configuration inversion of C-2-hydroxy in lycorine[J]. The Journal of Pharmaceutical Practice, 2016, 34(6): 511-515 |
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| Authors: | ZHAO Zeng XU Xusheng SUN Qingyan CHEN Hao LIU Runhui |
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| Affiliation: | Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective Study configuration inversion of C-2-hydroxy in lycorine to provide a foundation for semi-synthesis of asiaticumine B. Methods Use instrumental analyses to explore the C-2-hydroxy configuration through oxidation and reduction reactions. Results Accomplished configuration inversion of C-2-hydroxy in lycorine with 49% yield. Conclusion We identified a convenient and efficient method for the configuration inversion of C 2-hydroxy in lycorine. |
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| Keywords: | lycorine asiaticumine B configuration inversion |
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