OCT血管成像在原发性开角型青光眼早期诊断中的应用

目的：探讨光学相干断层扫描( optical coherence tomography,OCT)血管成像技术对原发性开角型青光眼( primary open angle glaucoma,POAG)早期诊断的价值。方法：观察31例31眼早期POAG患者视盘血流情况。以分光谱振幅去相关 OCT血管成像技术测量视盘周围毛细血管密度及视盘大血管直径,分析与患者视网膜神经纤维层厚度及视野平均缺损度的相关性。结果：视盘上方毛细血管平均密度为7.34±1.40根/mm,与上方视网膜神经纤维层平均厚度呈正相关(P<0.05)；视盘下方毛细血管平均密度为7.76±1.34根/mm与下方视网膜神经纤维层平均厚度呈正相关(P<0.05)。视盘大血管平均直径为94.71±11.20μm,与视野平均缺损度呈正相关(P<0.05)。结论：OCT血管成像可以方便无创观察青光眼患者视盘血流情况,可以作为原发性开角型青光眼早期诊断的参考指标。

Application of optical coherence tomography angiography in the early diagnosis of primary open angle glaucoma

?AIM: To investigate the diagnostic value of Application of optical coherence tomography ( OCT) angiography for early primary open angle glaucoma ( POAG) .?METHODS: Thirty- one eyes of 31 cases with early POAG were detected by OCT angiography. The split-spectrum amplitude-decorrelation angiography ( SSADA) algorithm was used to compute optic disc angiography. The vessel density of capillaries and caliber of large vessels around the optic disc were analyzed for the correlation with nerve fiber layer ( NFL ) thickness and mean defect of visual field.?RESULTS: The vessel density of capillaries was 7. 34 ± 1. 40 in superior and 7. 76±1. 34 in inferior, which showed a significant linear correlation with the NFL thickness ( P<0.05). The caliber of large vessels was 94. 71±11. 20μm, which had a linear correlation with the mean defect of visual field. (P<0. 05).? CONCLUSION: OCT angiography is a convenient technology to non - invasively measure optic disc perfusion and may be useful in the early diagnosis of primary open angle glaucoma.