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| 染料木素-β-环糊精包合物的制备和鉴定 | |
| 引用本文： | 雷英杰,石继仙,刘福德. 染料木素-β-环糊精包合物的制备和鉴定[J]. 中国药学杂志, 2004, 39(11): 837-838 |
| 作者姓名： | 雷英杰 石继仙 刘福德 |
| 作者单位： | 1. 天津大学药物科学与技术学院,天津,300072;天津理工学院生化学院,天津,300191 2. 天津大学药物科学与技术学院,天津,300072 3. 天津理工学院生化学院,天津,300191 |
| 摘 要： | 目的 制备染料木素β-环糊精包合物,提高药物的水溶性及稳定性。方法 通过饱和水溶液法制备出染料木素-β-环糊精包合物,并用紫外光谱、红外光谱、差示扫描量热和X-射线衍射分析等方法加以鉴定。结果 建立了一种制备染料木素β-环糊精包合物的方法。结论 β-环糊精包合物在水中的溶解度明显大于单体染料木素。 |
| 关 键 词： | 染料木素 β-环糊精 包合物 |
| 文章编号： | 1001-2494(2004)11-0837-03 |
| 收稿时间： | 2003-03-12; |
Preparation and characterization of inclusion complex of genistein with β-cy-clodextrin |
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| LEI Ying-jie,SHI Ji-xian,LIU Fu-de. Preparation and characterization of inclusion complex of genistein with β-cy-clodextrin[J]. Chinese Pharmaceutical Journal, 2004, 39(11): 837-838 | |
| Authors: | LEI Ying-jie SHI Ji-xian LIU Fu-de |
| Affiliation: | 1.College of Pharmaceuticals ＆ Biotechnology,Tianjin University,Tianjin 300072,China;2.Department of Biotech ＆ Chemical Engineering,Tianjin Institute of Technology,Tianjin 300191,China |
| Abstract: | OBJECTIVE To prepare inclusion complex of genistein with β-cyclodextrin in order to improve the drug's water-solubility and stability.METHODS The inclusion complex was prepared by the liquid-phase method in aqueous solution and characterized by DSC, IR,UV and X-ray analysis, respectively.RESULTS A method was developed for preparing the inclusion complex of genistein with β-cyelodex-trin.CONCLUSION The water-solubility of inclusion complex was greater than that of genistein. |
| Keywords: | genistein β-cyclodextrin inclusion complex. |
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