勃起功能障碍的药物治疗

近年来,特别是5型磷酸二酯酶抑制剂———西地那非上市以来,众多学者对勃起功能的生物化学和生理学进行了深入研究,在勃起功能障碍(ED)药物治疗的基础和临床方面取得了许多新的进展。本文综述了多种作用于中枢和外周ED治疗药物的分子及细胞作用机制,为最近ED药物研究和进展中最具争议的领域提供一些详细资料。

Pharmacotherapy for Erectile Dysfunction

In the recent few years, especially since the introduction of phosphodiesterase-5 inhibitor, sildenafil, most researchers have focused their researshes on biochemistry and physiology of erectile function. New progress has been made made in basic and clinic researches on pharmacotherapy for ED. In this article,the putative moleculars or cellular mechanism of actions of the available centrally and peripherally acting drugs are reviewed, providing details about the current and most explosive area of drug research and development in erectile dysfunction.