| 3-取代吲哚衍生物的合成(Ⅰ) |
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| 引用本文： | 楚勇,吕丁,徐鸣夏. 3-取代吲哚衍生物的合成(Ⅰ)[J]. 中国药物化学杂志, 2001, 11(1): 37-41 |
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| 作者姓名： | 楚勇 吕丁 徐鸣夏 |
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| 作者单位： | 1. 华西医科大学药学院药物化学教研室,四川 成都 610041
2. 四川抗菌素工业研究所,四川 成都 610051 |
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| 摘 要： | 基于吲哚衍生物和氮杂环衍生物的抗真菌活性，设计合成了含有噻二唑、三氮唑、二唑等氮杂环及其相应开链硫脲结构的吲哚衍生物和吲哚希夫碱化合物共18个，除化合物2、3和16外其余目标物未见报道，其结构经
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| 关 键 词： | 3-取代吲哚；噻二唑；三氮唑；二唑；合成；抗真菌 |
| 文章编号： | 1005-0108(2001)01-0037-05 |
| 修稿时间： | 2000-11-13 |
Synthesis of 3-SubstitutedIndole Derivatives( |
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| CHU Yong ,LU Ding ,XU Ming xia. Synthesis of 3-SubstitutedIndole Derivatives([J]. Chinese Journal of Medicinal Chemistry, 2001, 11(1): 37-41 |
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| Authors: | CHU Yong LU Ding XU Ming xia |
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| Affiliation: | CHU Yong 1,LU Ding 2,XU Ming xia 1 |
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| Abstract: | The increasing clinical importance of drug resistant bacterial pathogens has lent additional urgency to microbiological and antibacterial research.Eighteen new indolic derivatives containing 1,2,4 triazoles,1,3,4 thiadiazoles and their respective open chain thiosemicarbazides were synthesized for evaluating their antifungal activity.All the compounds besides 2,3,16 were reported for the first time and their chemical structures have been confirmed by means of their IR, 1H NMR,MS data.The antifungi tests of them are being in process. |
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| Keywords: | 3-substituted indole thiosemicarbazide 1 2 4 triazole 1 3 4 thiadiazole synthesis antifungal |
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