Complete Response of Highly Advanced Colon Cancer with Multiple Lymph Node Metastases to Irinotecan Combined with UFT: Report of a Case |
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Authors: | Yujiro Fujie Masataka Ikeda Iwao Seshimo Koji Ezumi Taishi Hata Tatsushi Shingai Masayoshi Yasui Osamu Takayama Hiroki Fukunaga Masakazu Ikenaga Ichiro Takemasa Hirofumi Yamamoto Masayuki Ohue Mitsugu Sekimoto Seiichi Hirota Morito Monden |
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Institution: | (1) Department of Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;(2) Department of Surgery, Osaka National Hospital, Osaka 540-0006, Japan;(3) Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537-8511, Japan;(4) Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan |
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Abstract: | Massive lymph node metastasis of the para-aortic region and supraclavicular lymph nodes, Virchow's lymph node metastasis due
to colon cancer, is extremely rare. We herein report a case of such systemic lymph node metastasis that was successfully treated
with a combination of irinotecan (CPT-11) and UFT, a combination drug of tegafur and uracil. The patient was a 57-year-old
woman who had a tumor in the ascending colon, and massively swollen para-aortic and supraclavicular lymph node metastasis.
She was treated with combination chemotherapy of CPT-11 and UFT. The main tumor was detected as a decompressed scar, and the
supraclavicular and para-aortic lymph nodes had completely disappeared after the second cycle of treatment. A histopathological
examination and immunohistochemistry with cytokeratin showed complete remission of adenocarcinoma in the tumor and para-aortic
lymph nodes. She remains alive without recurrence 52 months after chemotherapy. Combination chemotherapy of CPT-11 and UFT
may be of potential value in the treatment of advanced colorectal carcinoma, and both histopathological and immunohistochemical
confirmation of a complete remission may indicate prolonged disease-free survival. |
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Keywords: | Colon cancer Advanced lymph node metastasis CPT-11/UFT Immunohistochemistry Complete remission |
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