Vascular smooth muscle contraction/relaxation of rat carotid artery is not altered by bone grafting substitutes in vitro |
| |
Authors: | Ahmet Atila Ertan Nilufer Celebi Beriat Aylin Gürpinar Mehmet Ali Onur Murat Cavit Cehreli |
| |
Affiliation: | 1. Faculty of Dentistry, Department of Prosthodontics, Hacettepe University, Sihhiye, Ankara, 06100, Turkey 2. Faculty of Science, Department of Biology, Hacettepe University, Beytepe Campus, Ankara, Turkey 3. School of Dental Technology, Hacettepe University, Sihhiye, Ankara, 06100, Turkey 4. Section of Prosthodontics, CosmORAL Oral and Dental Health Polyclinics, Cankaya, Ankara, Turkey
|
| |
Abstract: | Purpose The aim of this study was to explore the effects of various bone grafting substitutes (Osteosponge®, Perioglas®, Tutoplast ®, and Surgibone®) on vascular smooth muscle tonus. Methods Bilateral carotid arteries were removed from rats and contraction/relaxation of isolated vessel rings were measured before and after contact with the biomaterials and then, for dose-dependent epinephrine and papaverin administrations, by a force displacement transducer. The data of each biomaterial group were collected by a computerized system and corresponding software at a sample rate of 1,000 kHz and were converted to contraction force. Results Vascular contraction forces were influenced in response to biomaterials tested except for Osteosponge (P?0.05), although the differences between groups were insignificant (P?>?0.05). There was a dose-dependent vascular response to epinephrine and papaverine administration upon biomaterial contact (P?0.05). The dose-dependent vascular responses to epinephrine and papaverine administration were almost similar for all biomaterials tested (P?0.05), suggesting that the biomaterials led to reversible effects on vascular contraction/relaxation behavior, which resulted in recovery. Conclusions Osteosponge®, Perioglas®, Tutoplast ®, and Surgibone® do not alter vascular smooth muscle tonus and vitality and therefore would, presumably, not jeopardize the angiogenesis of fresh blood vessels and full vascularization during tissue healing. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|