雷公藤多甙对银屑病患者T淋巴细胞亚群的作用及意义

目的 为了进一步了解银屑病发病与T淋巴细胞亚群的关系，探讨雷公藤多甙治疗进行期寻常型银屑病可能的发病机制。方法 将30例进行期建党型银屑病患者用雷公藤多甙治疗，同时取30例相应条件的正常人作为对照组。采用流式细胞信仪进行检测，观察患者组治疗前后与正常对照组外周血T淋巴细胞亚群的变化情况。结果 进行期银屑病患者治疗前外周血CD4^ 、CD4^ /CD8^ 、CD3^ 均较正常对照组显著降低，而CD8^ 升高，在治疗后CD3^ 、CD4^ 、CD4^ /CD8^ 较为正常。而CD8^ 无明显变化。结论 T淋巴细胞亚群CD4^ 、CD8^ 在银屑病发病中具有重要作用。雷公藤多甙是治疗进行期银屑病的一个有效药物，它的治疗作用可能是通过抑制T细胞活化而实现的。

Effects and significance of multiglucosid tripterygii on T-lymphocyte subsets of psoriasis patients

Objective To understand the relationship between T lymphocyte subsets and pathogenesis of psoriasis, and to explore the possible mechanism of multiglucosid tripterygii(MT) in the treatment of acute psoriasis vulgaris. Method Thirty patients with psoriasis were treated with MT. The changes of T lymphocyte subsets in peripheral blood from 30 patients with acute psoriasis vulgaris and healthy controls were detected by using flow cytometry. Results Compared with the normal control group, there was a significant decrease in the number of CD4 +?CD4 +/ CD8 +?CD3 +, a significant increase in the number of CD8 + and a significant variation in the number of CD4 +?CD4 +/ CD8 + and CD3 + in MT treated group, but no singificant variation in the number of CD8 + in MT treated group. Conclusion T lymphocyte subsets CD4 +?CD8 + play an important role in the pathogenesis of psoriasis. MT is effective in the treatment of acute psoriasis vulgaris. Its active mechanism might be suppression of the activation of T lymphocyte subsets.