| 高原地区缺血预处理对大鼠肝脏缺血再灌注的影响 |
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| 引用本文： | 祁夫魁,刘芳,王曙光,李昆. 高原地区缺血预处理对大鼠肝脏缺血再灌注的影响[J]. 局解手术学杂志, 2011, 20(4): 357-360 |
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| 作者姓名： | 祁夫魁 刘芳 王曙光 李昆 |
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| 作者单位： | 祁夫魁,刘芳,QI Fu-kui,LIU Fang(眉山市人民医院普通外科,四川,眉山,620010);王曙光,李昆,WANG Shu-guang,LI Kun(第三军医大学西南医院全军肝胆外科研究所,重庆,400038) |
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| 摘 要： | 目的研究在高原地区缺血预处理对大鼠肝脏缺血再灌注的影响。方法本组99只大鼠分为IPC1组、IPC2组及PTC组。观察并统计动物术后12、24、48、72 h存活率。术后12、24、48、72 h分别开腹,取心脏血、肝脏标本进行肝功能及病理检查。比较分析三组的病理改变、死亡率及肝功能指标变化。结果 IPC2组的ALT值及死亡率均明显高于PTC组与IPC1组,IPC1组的病理改变明显轻于IPC2组,而IPC2组与PTC组的病理改变相近。结论在高原地区反复短暂的组织器官缺血可致累加性损伤,最终导致组织坏死,器官功能衰竭。
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| 关 键 词： | 高原地区 缺血预处理 肝脏 缺血再灌注 |
Influence of ischemia preconditioning on hepatic ischemia-reperfusion injury of rats on plateau |
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| QI Fu-kui,LIU Fang,WANG Shu-guang,LI Kun. Influence of ischemia preconditioning on hepatic ischemia-reperfusion injury of rats on plateau[J]. Journal of Regional Anatomy and Operative Surgery, 2011, 20(4): 357-360 |
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| Authors: | QI Fu-kui LIU Fang WANG Shu-guang LI Kun |
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| Affiliation: | QI Fu-kui,LIU Fang,WANG Shu-guang,LI Kun(Department of General Surgery,People's Hospital of Meishan,Meishan Sichuan 620010,China) |
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| Abstract: | Objective To research into the effects of ischemic preconditioning(IPC) on hepatic ischemia-reperfusion injury of rats in the plateau region.Methods Totally 99 rats were divided into IPC1 group,IPC 2 group and portal trail clamp(PTC) group.The survival rate were observed and recorded at 12,24,48 and 72 h after surgery respectively.Meanwhile,the blood and tissue samples were collected to do liver function and pathological examinations.The pathological changes,motality rates and changes in liver function were... |
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| Keywords: | high altitude ischemic preconditioning liver ischemia-reperfusion |
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