| 赤芍总苷对沙土鼠全脑缺血再灌注损伤的保护作用 |
| |
| 摘 要： |
|
| 关 键 词： | 赤芍总苷 沙土鼠 全脑缺血再灌注损伤 |
Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils] |
| |
| Ren-Qiang Ma,Jian-Wen Chen,Jian-Xin Pang,Xiu-Jian Lan,Can-Hua Qiu. Protective effects of total paeony glycoside against global cerebral ischemia-reperfusion injury in gerbils][J]. Journal of First Military Medical University, 2005, 25(4): 471-473 |
| |
| Authors: | Ren-Qiang Ma Jian-Wen Chen Jian-Xin Pang Xiu-Jian Lan Can-Hua Qiu |
| |
| Affiliation: | School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510080, China. |
| |
| Abstract: | OBJECTIVE: To study the protective effects of the total paeony glycoside (TPG) against global cerebral ischemia-reperfusion injury in gerbils. METHODS: Gerbils models of global cerebral ischemia-reperfusion injury were prepared by bilateral common carotid artery ligation for 12 min followed by 24-hour reperfusion. The effects of TGP on brain edema index, superoxide dismatase (SOD) activity and malonaldehyde (MDA) concentration of the cerebral tissue homogenate and pathology of the brain were examined 24 h after model establishment. RESULTS: Compared with the model group, TPG at the doses of 200 and 400 mg/kg could significantly relieve brain edema, enhance SOD activity and lower MDA concentration in the gerbils. Pathological examination showed that the gerbils with TPG treatment had milder injury of the cells in the hippocampal CA1 region. CONCLUSIONS: TPG has obvious protective effects against global cerebral ischemia-reperfusion injury. |
| |
| Keywords: | |
|
|
