Modulation by malaria infection of the induction of T lymphocyte-dependent delayed-type hypersensitivity and antibody formation to sheep erythrocytes in mice |
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| Authors: | J.C. MICHEL P.H. LAGRANGE B. HURTREL |
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| Affiliation: | Unitéd'Immunophysiologie cellulaire, Département de Biologie moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France |
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| Abstract: | A profound alteration of the inductive phase of delayed-type hypersensitivity and antibody formation to SRBC was found in malaria infected mice when sensitization with this antigen was performed intravenously at a critical time of the disease, but not after subcutaneous immunization, suggesting a major role for the spleen in the mechanism of immunodepression. |
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| Keywords: | rodent malaria immunosuppression sheep red blood cells delayed-type hypersensitivity antibody formation |
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