|
|||||
|
|
| 环氧合酶及其抑制剂与肿瘤防治的研究进展 | |
| 引用本文： | 卢丽娜,杨婷,庄则豪. 环氧合酶及其抑制剂与肿瘤防治的研究进展[J]. 中国临床药理学与治疗学, 2006, 11(1): 22-26 |
| 作者姓名： | 卢丽娜 杨婷 庄则豪 |
| 作者单位： | 1. 福建省老年医院药剂科,福州,350001,福建 2. 福建省血液病研究所,福州,350001,福建 3. 福建医科大学消化系病研究室,福州,350005,福建 |
| 摘 要： | 环氧合酶（COX）及其抑制剂是近年肿瘤防治研究的热点之一。目前认为，COX通过多种途径参与肿瘤的发生发展，COX抑制对结肠癌等多种肿瘤有预防作用，也可能增强肿瘤的放化疗疗效，但安全性及有效性均不理想，且可能存在非COX途径。因此，COX作为肿瘤防治靶点的临床价值还有待进一步评价。 |
| 关 键 词： | 非甾体类抗炎药 选择性环氧合酶2抑制剂 肿瘤治疗 肿瘤预防 |
| 文章编号： | 1009-2501(2006)01-0022-05 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2005-11-25 |
Role of cyclooxyenase and its inhibitors in prevention and treatment of cancer |
|
| LU Li-na,YANG Ting,ZHUANG Ze-hao. Role of cyclooxyenase and its inhibitors in prevention and treatment of cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(1): 22-26 | |
| Authors: | LU Li-na YANG Ting ZHUANG Ze-hao |
| Affiliation: | Department of Pharmacy, Fufian Geriatrics Hospital, Fuzhou 350001, Fujian , China ; 1 Institute of Hematology of Fujian, Fuzhou 350001, Fujian, China; 2 Laboratory of Gastroenterology, Fujian Medical University, Fuzhou 350005, Fujian, China |
| Abstract: | Cyclooxygenase(COX) and its inhibitors were widely studied for the prevention and treatment of cancer.It is believed that COX is involved in the carcinogenesis through different pathways.COX inhibitors play some roles in the prevention for colon cancer and many other cancers,and can enhance the effects of radio-and chemotherapy.However,the safety and efficacy of those agents are far form perfect.There has COX independent pathway counted for the anti-cancer effects of COX inhibitors as well.Therefore,further studies should be taken to evaluate the value of COX as a target of cancer prevention and treatment in clinical. |
| Keywords: | nonsteroidal anti-inflammatory drugs selective COX-2 inhibitor oncotherapy cancer prevention |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |