胸腺肽应用于复发性单纯疱疹病毒性角膜炎外周血T淋巴细胞亚群观察

目的:探讨胸腺肽(thymosin)治疗复发性单纯疱疹性病毒性角膜炎外周血T淋巴细胞亚群。方法:收集复发性单纯疱疹病毒性角膜炎患者33例、健康对照者28例,应用流式细胞仪技术测定T细胞亚群。结果:复发性单纯疱疹病毒性角膜炎患者治疗前CD3、CD4明显下降(P<0.05),CD8升高,CD4/CD8比值下降(P<0.05)。23例痊愈患者治疗后T淋巴细胞亚群接近正常水平,而6例未痊愈患者治疗后T淋巴细胞亚群虽有所提高,但仍低于健康对照(P<0.05)。结论:复发性单纯疱疹病毒性角膜炎患者细胞免疫功能降低,胸腺肽肠溶片能够增强患者细胞免疫功能,取得较好效果。

Effect of thymosin on herpes simplex keratitis and the change of T lymphocytes Subgroup in peripheral blood

AIM:To explore the effect of thymosin on cytoimmunity of herpes simplex keratitis(HSK)and the change of T lymphocytes subgroup in peripheral blood.· METHODS:Thirty-three cases of recurrent HSK and 28 cases of healthy controls were collected.The levels of CD3,CD4,and CD8 were detected by using flow cytometry technology.· RESULTS:Before the treatment,CD3,CD4,CD4/CD8 of the recurrent HSK patients decreased(P<0.05),while the level of CD8 rose.After the treatment,T lymphocytes subgroup approached to the normal level in 23 cases who had complete recovery.The level of T lymphocytes subgroup were raised to some extent but still lower than that of normal controls in six cases who did not recover completely.· CONCLUSION:Cell-mediated immunity decreased in patients with recurrent herpes simplex keratitis.Thymosin can improve the curative effects on recurrent HSK and enhance the cytoimmunity of HSK patients.