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Fracture risk in patients receiving acid-suppressant medication alone and in combination with bisphosphonates |
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| Authors: | F de Vries A L Cooper S M Cockle T-P van Staa C Cooper |
| Institution: | (1) Utrecht Institute for Pharmaceutical Sciences, Universiteit Utrecht, Utrecht, The Netherlands;(2) General Practice Research Database, MHRA, London, UK;(3) Bridge Medical Centre, Crawley, UK;(4) Servier Laboratories Ltd., Wexham, Slough, UK;(5) MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK;(6) Norman Collisson Chair of Musculoskeletal Sciences, University of Oxford, Oxford, UK |
| Abstract: | SummaryPrevious studies have found an association between acid suppressants and fracture risk. We assessed fracture risk in patients taking concomitant acid suppressant and bisphosphonates. Positive associations were observed for any hip and vertebral fracture. The effect size was modest; however, the significance lies in the widespread prescribing of acid suppressants. |
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