Intra-uterine environment influences glomerular number and the acute renal adaptation to experimental diabetes |
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Authors: | S E Jones R W Bilous A Flyvbjerg S M Marshall |
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Institution: | (1) School of Clinical Medical Sciences, University of Newcastle upon Tyne. UK, GB;(2) Department of Diabetes and Endocrinology, Aarhus Kommunehospital, Aarhus, Denmark, DK |
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Abstract: | Aims/hypothesis. We sought to test the hypothesis of whether low birth weight rats would have reduced glomerular number, higher systolic blood
pressure and an altered acute response to streptozotocin diabetes compared to normal birth weight rats. Methods. Female offspring of Wistar rats fed an isocaloric diet containing either 6 % casein (LPD) or 18 % casein (NPD) in utero were
studied. Birth weight, body weight, systolic blood pressure and urine albumin excretion were measured before and after streptozotocin
diabetes. Glomerular number and volume were estimated after one week of diabetes. Results. The LPD rats were of low birth weight (5.4 ± 0.5 g vs 6.4 ± 0.8 g, p < 0.0001) with higher systolic blood pressure (137 ± 9 mmHg vs 120 ± 7 mmHg, p < 0.0001) and reduced glomerular number (17 435 ± 2074 vs 24 846 ± 1864, p < 0.0001). The LPD rats had smaller kidneys (0.925 ± 0.009 g vs 1.200 ± 0.173 g, p = 0.041) but similar glomerular volume to NPD control rats (1.11 ± 0.15 · 106μm3 vs 1.08 ± 0.17 · 106μm3). After 1 week of diabetes LPD rats had a greater proportional increase in renal size (diabetes 50 ± 12 % vs control 20 ±
4 %, p = 0.003). Insulin suppressed renal hypertrophy in both LPD and NPD rats but failed to suppress glomerular hypertrophy in
LPD rats (1.48 ± 0.21 · 106μm3 vs 1.03 ± 0.23 · 106μm3
p = 0.015). Conclusion/interpretation. Abnormal intra-uterine environment reduces both renal size and glomerular number and influences the acute renal adaptation
to experimental diabetes. Diabetologia (2001) 44: 721–728]
Received: 25 September 2000 and in revised form: 26 February 2001 |
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Keywords: | Intra-uterine environment glomerular number glomerular volume diabetic nephropathy |
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