| IDO信号通路在非小细胞肺癌放疗的应用进展 |
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| 引用本文： | 吴林芳,王春雨,杨宇帆,毕楠,王绿化. IDO信号通路在非小细胞肺癌放疗的应用进展[J]. 中华放射肿瘤学杂志, 2022, 31(2): 219-222. DOI: 10.3760/cma.j.cn113030-20200619-00315 |
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| 作者姓名： | 吴林芳 王春雨 杨宇帆 毕楠 王绿化 |
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| 作者单位： | 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院放疗科,北京 100021;国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院,深圳 518116 |
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| 摘 要： | 吲哚胺-2，3-双加氧酶(IDO)是色氨酸(Trp)降解为犬尿氨酸(Kyn)的限速酶，炎症因子IFN-γ可以提高IDO活性，使Kyn/Trp即K/T比增加，从而降低CD 8+T细胞及调节性T细胞活性，介导肿瘤的免疫逃逸。放疗是非小细胞肺癌综合治疗中的重要手段，可以双向调控机体免疫应答，协同免疫抑制剂发挥抗肿瘤...
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| 关 键 词： | 吲哚胺-2，3-双加氧酶 肿瘤，非小细胞肺/放射疗法 免疫 |
| 收稿时间： | 2020-06-19 |
Research progress on the role of IDO signaling pathway in radiotherapy for non-small cell lung cancer |
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| Wu Linfang,Wang Chunyu,Yang Yufan,Bi Nan,Wang Lyuhua. Research progress on the role of IDO signaling pathway in radiotherapy for non-small cell lung cancer[J]. Chinese Journal of Radiation Oncology, 2022, 31(2): 219-222. DOI: 10.3760/cma.j.cn113030-20200619-00315 |
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| Authors: | Wu Linfang Wang Chunyu Yang Yufan Bi Nan Wang Lyuhua |
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| Affiliation: | Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China |
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| Abstract: | Indoleamine 2,3-dioxygenase(IDO)is one of the rate-limiting enzymes that degrade tryptophan(Trp)into kynurenine(Kyn).Inflammatory factor IFN-γ mediates tumor′s immune escape by activating the IDO signaling pathway,upregulating theKyn/Trp(K/T ratio)and suppressing the activity of both CD8+T and regulatory T cells.Radiotherapy plays a major role in treating non-small cell lung cancer.It not only bi-directionally regulates immune response of the host,but also collaborates with immunosuppressive agents to kill tumors.Meanwhile,immune status of the host can affect the therapeutic effect of radiotherapy.In recent years,studies have shown that IDO activity levels change before and after radiotherapy and is related to clinical prognosis.Nevertheless,relevant mechanism remains unclear.This article aims to elucidate the application of IDO signaling pathway in radiotherapy for non-small cell lung cancer. |
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| Keywords: | Indoleamine 2,3-dioxygenase Neoplasm,non-small cell lung/radiotherapy Immune |
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