大鼠心肌梗死后应用瑞舒伐他汀对左室重构和心功能的影响

目的:探讨大鼠心肌梗死后应用瑞舒伐他汀对左室重构和心功能的影响。方法:30只健康成年雄性SD大鼠随机分为正常组、心梗组和瑞舒伐他汀治疗组(瑞舒伐他汀10mg/kg加入2ml蒸馏水每天灌胃1次,持续6周)。治疗前后分别检测3组大鼠的左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、舒张末期左室后壁厚度(LVPWD)、左室射血分数(LVEF)和短轴缩短率(LVFS);6周后测定左室血流动力学指标,包括左室收缩压(LVSP)和左室舒张末压(LVEDP);大鼠处死后,测量左心室重量及左心重量指数。结果:治疗6周后,与正常组相比,心梗阻和治疗组的左心室重量及左心室重量指数均显著增加,动脉压各指标(SBP、DBP、MBP)和LVSP均显著降低,LVEDP则显著升高。但与心梗组比较,治疗组的左心室重量及左心室重量指数均显著降低,SBP、DBP、MBP和LVSP均显著提高,LVEDD、LVESD与LVPWD均明显降低,LVEF与LVFS则显著升高。结论:大鼠心肌梗死后应用瑞舒伐他汀可以明显改善左室重构和左室功能。

Influence of Rosuvastatin on Left Ventricular Remodeling and Cardiac Function of Rats After Myocardial Infarction

Objective:To investigate the influence of rosuvastatin on left ventricular remodeling and cardiac function of rats after myocardial infarction.Methods:Thirty healthy adult male SD rats were randomly divided into normal group,myocardial infarction group,and rosuvastatin treated group (rosuvastatin 10mg/kg per day for 6 weeks).Three groups underwent echocardiographic examination to determine left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),end-diastolic left ventricular posterior wall thickness(LVPWD),left ventricular ejection fraction(LVEF)and fractional shortening rate(LVFS)before and after treatment;left ventricular hemodynamics indices,such as left ventricular systolic pressure(LVSP) and left ventricular end-diastolic pressure(LVEDP),were measured after 6 weeks;and after the rats were killed,left ventricular mass and left ventricular mass index(LVMI)were measured.Results:Compared with that respectively in normal control group,after 6 weeks,left ventricular mass and LVMI of myocardial infarction group and rosuvastatin group were significantly increased,artery pressure indices(SBP,DBP,MBP),and LVSP were significantly decreased, LVEDD,LVESD and LVPWD were increased significantly,and LVEF and LVFS significantly decreased.But the changes of these indices could be relieved by 6 weeks'rosuvastatin treatment.Conclusion:Application of rosuvastatin in rats after myocardial infarction can significantly improve left ventricular remodeling and left ventricular function.