胃癌术后腹腔种植转移危险因素的多因素回归分析

目的:探讨胃癌术后腹腔种植转移的危险因素。方法:从我院1998年2月至2008年6月间胃癌病例数据库中筛选出60例胃癌术后患者,病例组30例发生腹腔种植转移,对照组30例无任何复发(随访时间大于3年),回顾性分析比较两组病例的临床病理特征,包括肿瘤部位、胃壁浸润深度、Borrmann分型、TNM分期、淋巴结转移等研究指标,探讨其与术后腹腔种植转移的关系。结果:单因素分析显示,胃癌术后腹腔种植转移与肿瘤大小、胃壁浸润深度、淋巴结转移、TNM分期、Borrmann分型、术前血清CEA水平有关(P<0.05);多因素回归分析筛选出淋巴结转移为腹腔种植转移的独立相关因素(P<0.01)。结论:淋巴结转移是胃癌术后腹腔种植转移的发生发展中的最重要因素。

Multiple Regression Analysis of Factors Related to the Peritoneal Metastasis Following Curative Resection for Gastric Cancer

Objective:To investigate the risk factor(s) of peritoneal metastasis for gastric cancer patients who received curative resection.Methods:Sixty cases of gastric cancer,including 30 cases with peritoneal metastasis and 30 cases without recurrence were retrospectively reviewed.Clinicopathologic variables including tumor size,location,depth of infiltration,Borrmann type,TNM stage,and lymph node metastasis,etc.,were analyzed.Results:Univariate analysis showed that tumor size,depth of invasion,lymph node metastasis,TNM stage,Borrmann type,and preoperative serum-CEA level were risk factors for peritoneal metastasis(P<0.05).Multivariate logistic regression analysis revealed that the only independent risk factor of peritoneal metastasis was lymph node metastasis among all the clinicopathologic variables(P<0.01).Conclusion:Gastric cancer patients with lymph node metastasis tended to have greater risk of peritoneal metastasis after curative resection.The lymph node metastasis correlates closely with the peritoneal metastasis after curative resection for gastric cancer.