| 鲨肝肽对CCl4所致大鼠慢性肝损伤的治疗作用 |
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| 引用本文： | 郭昱,吴梧桐,窦昌贵. 鲨肝肽对CCl4所致大鼠慢性肝损伤的治疗作用[J]. 药物生物技术, 2001, 8(2): 86-89 |
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| 作者姓名： | 郭昱 吴梧桐 窦昌贵 |
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| 作者单位： | 1. 中国药科大学生物制药学院，南京 210009
2. 海洋药物研究所，南京 210009 |
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| 基金项目： | 江苏省自然科学基金资助（BK97081）和国家海洋863资助（No.819-05-07） |
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| 摘 要： | 从海洋生物鲨鱼肝脏纯化获得一种活性多肽—鲨肝肽，研究了其对CCl
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| 关 键 词： | 鲨肝肽；慢性肝损伤；治疗作用；纤维化 |
| 文章编号： | 1005-8915(2001)02-086-04 |
| 修稿时间： | 2000-08-20 |
Therapeutic Effects ofShahepatide on Chronic Liver Injury Induce d by CCl4 in Rats |
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| Guo Yu,Wu Wutong,Dou Changgui. Therapeutic Effects ofShahepatide on Chronic Liver Injury Induce d by CCl4 in Rats[J]. Pharmaceutical Biotechnology, 2001, 8(2): 86-89 |
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| Authors: | Guo Yu Wu Wutong Dou Changgui |
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| Abstract: | An active polypeptide ，named Shahepatide ，was ex tracted and purified from Shark liver. This article investigated its therapeutic effects on chronic liver injury induced by CCl4 in rats. The results showed that Shahepatide cou ld s uppress the elevation of ALT, AST and hydroxyproline in serum of liver injury r ats induced by CCl4, and could increase albulmin level and the ratio of albul min and globulin in serum. Hepatic histological findings indicated that Shahepatide could alleviate hepatic fibrosis.The results implied that Shahepatide had more r esearch and application values on treating cirrhosis of the liver and chronic he patitis. |
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| Keywords: | Shahepatide Chronic liver injury Therapeutic effect |
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