| 血红素氧合酶-1/一氧化碳系统与急性肺损伤 |
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| 引用本文： | 安莉,俞森洋. 血红素氧合酶-1/一氧化碳系统与急性肺损伤[J]. 医学综述, 2007, 13(3): 163-165 |
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| 作者姓名： | 安莉 俞森洋 |
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| 作者单位： | 中国人民解放军总医院南楼呼吸科,北京,100853 |
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| 摘 要： | 血红素氧合酶-1/一氧化碳(HO-1/CO)系统在多种应激状态下诱导产生,通过抗氧化、抗炎、抗凋亡等机制发挥组织器官保护作用,基因治疗、药物诱导HO-1高表达或外源性CO可能成为治疗多种疾病的新途径。本文就HO-1/CO系统的产生、调控及在急性肺损伤中的表达和作用简要综述。
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| 关 键 词： | 急性肺损伤 血红素氧合酶-1 一氧化碳 胆红素 |
| 文章编号： | 1006-2084（2007）03-0163-03 |
| 收稿时间： | 2006-06-20 |
| 修稿时间： | 2006-12-13 |
Heme Oxygenase-1/Carbon Monoxide and Acute lung injury |
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| AN Li,YU Sen-yang. Heme Oxygenase-1/Carbon Monoxide and Acute lung injury[J]. Medical Recapitulate, 2007, 13(3): 163-165 |
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| Authors: | AN Li YU Sen-yang |
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| Affiliation: | Department of Respiratory Diseases, General Hospital of PLA , Beijing 100853, China |
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| Abstract: | Heme Oxygenase-1/Carbon Monoxide system(HO-1/CO) is induced by various stimuli and stresses,which exerts cytoprotection through antioxidation,antiinflammatory and antiapoptosis.Upregulation of HO-1 through gene therapy and pharmacological induction as well as exogenous carbon monoxide may provide new way for future disease therapy.This article summarize HO-1/CO about its production,regulation and its expression and effect in acute lung injury. |
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| Keywords: | Acute lung injury Heme Oxygenase-1 Carbon Monoxide Bilirubin |
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