| 中国独龙族人群中CYP 2C19基因多态性的分布 |
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| 引用本文： | 叶峻杰,彭林,张松,唐莉,焦云萍,董兆文. 中国独龙族人群中CYP 2C19基因多态性的分布[J]. 中国新药杂志, 2004, 13(3): 266-268 |
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| 作者姓名： | 叶峻杰 彭林 张松 唐莉 焦云萍 董兆文 |
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| 作者单位： | 1. 云南省计划生育技术科学研究所,昆明650021
2. 国家计划科学技术研究所,北京100081 |
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| 摘 要： | 目的:研究细胞色素P450 2C19(CYP 2C19)基因在中国云南独龙族人群中的基因型及突变频率.方法:采用聚合酶链式反应(PCR)与限制性内切酶片段长度多态性技术,分析205例独龙族人的基因型.结果:84例为CYP 2C19野生型纯合子(wt/wt);98例为CYP 2C19m1杂合子(wt/m1);23例为CYP 2C19m1突变型纯合子(m1/m1),CYP 2C19m1突变频率为0.351.结论:中国云南独龙族人群P450 2C19存在突变,突变频率与国内各种族相比具有一定的可比性.
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| 关 键 词： | 细胞色素P450 2C19 基因型 聚合酶链式反应 |
| 文章编号： | 1003-3734(2004)03-0266-03 |
The gene diversity distribution of metabolic enzyme CYP2C19 in Chinese Dulong population |
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| YE Jun-jie,PENG Lin,ZHANG Song,TANG Li,JIAO Yun-ping,DONG Zhao-wen. The gene diversity distribution of metabolic enzyme CYP2C19 in Chinese Dulong population[J]. Chinese Journal of New Drugs, 2004, 13(3): 266-268 |
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| Authors: | YE Jun-jie PENG Lin ZHANG Song TANG Li JIAO Yun-ping DONG Zhao-wen |
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| Abstract: | Objective: To study the genotype and mutation rate of cytochrome P450 2C19 in Dulong population,a minority nationality in Yunnan province of China. Methods:The genotypes of 205 Dulong subjects were studied by PCR and PFLP (restricted fragment length polymorphism) technique .Results:It indicated that among 205 subjects studied,84 were homozygous for wild type (wt/ wt) ,98 were heterozygous for CYP 2C19 ml (wt/ml) and 23 were homozygous for CYP 2C19ml(ml/ ml) with a mutation rate of 0.351. Conclusion:There are P450 2C19 mutations among Duong population in Yunnan province of China with a mutation rate comparable to other nationalities in China. |
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| Keywords: | cytochrome P450 2C19 genotype polymerase chain reaction |
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