Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior |
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| Authors: | V Molina L Ciesielski S Gobaille P Mandel |
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| Affiliation: | 1. Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal;2. R&D, Drug Product Development, Hovione FarmaCiencia SA, Lisbon, Portugal;3. University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research, Coimbra, Portugal;1. School of Pharmaceutical Sciences, Jaipur National University, Jaipur 302 017, Rajasthan, India;2. Department of Pharmaceutics, STES''s Sinhgad Institute of Pharmacy (Affiliated to Savitribai Phule Pune University), Narhe, Pune 411 041, Maharashtra, India;3. School of Pharmacy, Faculty of Health and Medical Science, Taylor''s University, Subang Jaya, Selangor, Malaysia;4. Centre for Drug Delivery and Molecular Pharmacology, Faculty of Health and Medical Sciences, Taylor''s University, Subang Jaya, Selangor, Malaysia;5. Department of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, Malaysia;6. Centre for Bioactive Molecules and Drug Delivery, Institute for Research, Development and Innovation, International Medical University, Bukit jalil, 57000 Kuala Lumpur, Malaysia;1. Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter u. 50A, H-1083 Budapest, Hungary;2. Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107 Reykjavík, Iceland |
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| Abstract: | Intra olfactory bulb administration of three classes of GABA-mimetics (GABAa agonists, inhibitors of reuptake, inhibitors of GABA degradation) clearly inhibit mouse-killing behavior, without sedation. A linear correlation is observed between GABA levels increase in the olfactory bulbs and muricidal inhibition following local injection of valproic acid and gamma-vinyl GABA, two GABA-T inhibitors; the differences observed between these two compounds may be due to the differences in their mechanism of action on GABA-T activity and to the different pool of GABA on which they act. No diffusion to extra bulbar sites were observed after local administration of gamma-vinyl GABA. This evidence suggests an inhibitory role of GABA from olfactory bulbs in the modulation of mouse-killing behavior. |
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