Determination of 9-hydroxyellipticine by redox colorimetry. |
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| Authors: | P Formisyn F Pautet C Tran Minh J Bourgois |
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| Affiliation: | Ecole des Mines de Saint-Etienne, Laboratoire de Génie industriel & Biotechnologie, France. |
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| Abstract: | The chemical reactions involved in the decomposition of 9-hydroxyellipticine (9-OH-E), an anticancer agent, in polar solvents is explained. The reactions, which involve the formation of 9-oxo-ellipticine and the addition of a nucleophilic acid on the C10 site of the heterocyclic system, have been used to measure 9-OH-E quantitatively by colorimetry in solution and by reflection on paper surfaces. A method for the stabilization of 9-OH-E in polar solvents is proposed. |
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