| FUDR为主方案治疗晚期非小细胞肺癌的研究 |
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| 引用本文： | 王淑琴,刘巍,王玉华,翟宝娥.FUDR为主方案治疗晚期非小细胞肺癌的研究[J].中国肺癌杂志,2002,5(4):290-292. |
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| 作者姓名： | 王淑琴 刘巍 王玉华 翟宝娥 |
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| 作者单位： | 050011,石家庄,河北医科大学四院肿瘤科 |
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| 摘 要： | 目的 探讨氟脲脱氧核苷 (floxuridine ,FUDR ,氟苷 )为主方案治疗晚期非小细胞肺癌的疗效和毒性。方法 A组 (观察组 ) 5 0例 ,接受L/FUDR EP方案治疗 ;B组 (对照组 ) 42例 ,接受L/FEP方案治疗。每组均行 3程化疗方评价疗效。结果 A、B两组疗效分别为 40 .0 % (2 0 / 5 0 )及 3 8.1% (16/ 42 ) (P >0 .0 5 )。A组骨髓抑制、消化道反应、脱发、局部静脉炎发生率低于B组 (P <0 .0 1)。结论 FUDR为主方案治疗晚期NSCLC疗效确切 ,毒性较 5 FU低 ,值得临床推广应用。
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| 关 键 词： | FUDR 化学疗法 毒副反应 临床研究 晚期 非小细胞肺癌 |
| 修稿时间： | 2001年11月23 |
The efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer |
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| WANG Shuqin,LIU Wei,WANG Yuhua,ZHAI Baoe.The efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer[J].Chinese Journal of Lung Cancer,2002,5(4):290-292. |
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| Authors: | WANG Shuqin LIU Wei WANG Yuhua ZHAI Baoe |
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| Institution: | WANG Shuqin,LIU Wei,WANG Yuhua,ZHAI Baoe. Department of Medical Oncology,The Fourth Hospital,Hebei Medical University,Shijiazhuang,Hebei 050011,P.R.China |
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| Abstract: | Objective To evaluate the efficacy and toxicity of the FUDR based regimen in the treatment of advanced non small cell lung cancer. Methods Fifty patients in group A received the L/FUDR EP regimen, while 42 patients in group B were given the L/FEP regimen. The response and toxicity were evaluated after three courses of treatment.Results The therapeutic response of group A and group B were 40.0% and 38.1% respectively (P>0.05). The toxicities such as marrow inhibition, gastrointestinal symptoms, alopecia and local phlebitis were remarkably lower in group A than those of group B (P<0.01). Conclusion The FUDR based regimen is effective to the advanced NSCLC, and its toxicity is lower than 5 FU. |
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| Keywords: | Non small cell lung cancer Efficacy Toxicity |
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