男性肺癌的遗传流行病学研究

为深入研究宣威县男性肺癌的病因，探讨遗传因素的作用，分析了１９４例男性肺癌先证者的核心家系和１７６例男性对照的核心家系资料。结果发现，肺癌先证者的亲属（父母、同胞）患肺癌的危险性是对照组的１．７８倍，且差异有显著性。其中，父母及女性亲属患肺癌的危险性分别是对照组的２．９０倍和２．４３倍，差异均有显著性意义。肺癌的遗传度为２４．６８％。女性对肺癌的遗传易患性比男性高，遗传因素是肺癌的重要危险因素。

Genetic Epidemiological Studies on Mal e Lung Cancer

ata of nuclear families of 194 male proband with lung cancer and 176 controls were analyzed to study its genetic etiology in Xuanwei County of Yunnan Province.Results showed risk of lung cancer in the relatives (parents and siblings)of the proband was 1. 78 times as of controls,with a statistically significant difference,and risks in parents and female relatives of the proband were 2.90 and 2.43 times as in controls,respectively, both with a statistically significant difference,Heritability of male lung can-cer was 24. 68%. It indicated genetic susceptibility to lung cancer in females was higher than that in males and played an important role in the etiology of lung cancer.