碳青霉烯类抗生素连续5年用药密度及细菌耐药性分析

目的:探讨碳青霉烯类抗生素用药密度变化对细菌耐药性所产生的影响。方法:对某院ICU病房碳青霉烯类抗生素的用药密度、相关致病菌的种类构成和耐药监测结果进行连续5年的年度分布汇总,分析对应时段的量变数据。结果:非发酵革兰阴性菌(NFGNB)对碳青霉烯类抗生素易产生耐药,且耐药率随用药密度的升降而波动。肠杆菌属细菌对碳青霉烯类的耐药率低,受用药密度的影响较小。结论:碳青霉烯类抗生素的用药密度与NFGNB耐药率的变化呈正相关。合理控制用药密度可使细菌耐药率减缓或下降。

Use Density of Carbapenems and Bacterial Drug Resistance in 5 Consecutive Years

OBJECTIVE： To investigate the effect of the correlation between the use density of carbapenems and the bacterial drug-resistance. METHODS： The data including the use density of carbapenems in the ICU ward of a hospital, the categories of the related pathogenic bacteria and monitoring results on drug resistances in 5 consecutive years were collected for an analysis of the quantitative change in a corresponding stage. RESULTS： Non - fermentative Gram - negative bacilli （NFGNB） were prone resistant to carbapenems and the resistant rate fluctuated in relation to the use density of carbapenems. The Enterobacter had low resistance to carbapenems and was independent of the use density of carbapenems. CONCLUSION： The use density of carbapenems has a positive correlation with the resistance of NFGNB. Reasonable drug use density may slow down or reduce bacterial drug - resistance.