缺血性脱髓鞘区与正常脑白质的磁共振弹性成像对比研究

目的 通过磁共振弹性成像（magnetic resonance elastography，MRE）分析缺血性脱髓鞘区与正常脑白质的剪切模量是否存在差异。方法 选取2009年间于北京天坛医院就诊，行常规序列扫描，诊断为Fazekas scale Ⅱ级或以上的缺血性脱髓鞘患者14例，正常对照组选取2009年间正常志愿者16例。所有受试者均行MRE，将所得原始图像经计算机处理后，分别测得患者半卵圆中心脱髓鞘区、正常志愿者半卵圆中心的剪切模量。结果 所有患者均成功获取双侧半卵圆中心脱髓鞘区的剪切模量，右侧为（8.7±3.0）kPa，左侧为（10.9±2.5）kPa。所有正常志愿者均成功获取双侧半卵圆中心的剪切模量，右侧为（16.6±4.5）kPa，左侧为（16.4±3.7）kPa。两组间差异具有统计学差异（P <0.01）。结论 缺血性脱髓鞘区的剪切模量低于正常脑白质的剪切模量。

The Comparative Study of Ischemic Demyelination and Normal White Matter on Magnetic Resonance Elastography

Objective To compare the shear stiffness between ischemic demyelination and normal white matter by using Magnetic Resonance Elastography （MRE）. Methods Patients group： 14 consecutive patients with ischemic demyelination at the grade of Fazekas scale II or above defined by routine MR sequences scan in 2009 were involved. Control group： 16 human volunteers in 2009 were enrolled. All the subjects underwent head MRE. After postprocessing raw images by computer, shear modulus of ischemic demyelination area within semioval centre in patients group and normal semioval centre in control group were seperatively messured. We used independent-sample T test to analyze the difference between ischemic demyelination and normal white matter. Results All the shear modulus of research areas in two groups were successfully obtained, with the result of right side（8.7±3.0）kPa, and left side（10.9±2.5）kPa in patients group, while right side（16.6 ±4.5）kPa, and left side（16.4±3.7）kPa in control group, which were significant different. Conclusion The shear stiffness of ischemic demyelination was significantly lower than that of normal white matter.