多药耐药相关蛋白基因表达与卵巢癌病理特征的关系

The Ciinicopathoiogical Study on Expression of Multi-drug Resistance-Associated Gene in Primary Ovarian Cancer

Objective To explore the association between the expression of multi-drug resistance-associated protein（MRP） and the elinicopathological features of the primary epithelial ovarian cancer（ PEOC）, and to investigate the clinical significance of the expression of MRP gene in PEOC. Methods Using the reverse transcfiption-polymerase chain reaetion（PT-PCR） assay,the expressions of MRP gene in 37 PEOC, 10 normal ovary tissues and 20 peripheral blood monouclear cells（PBMC） samples were examined. Results The expressions of MRP gene in PEOC were higher than those in ovarian tissues （ P 〈 0. 05 ）. But compared with PBMC, there were no differences（ P 〉 0. 05 ）. There were no correlations respectively between MRP gene expressions and FIGO stage or histological type of PEOC. But the poorly the histological differentiation was,the higher the expression of MRP gene was. Patients with MRP gene high expression tumors had a significantly shorter progression-free survival than those with MRP gene low expression. Conclusions MRP gene expression related to resistance of PEOC are major causes of resistance to MDR related drug. Detecting the expression of MRP gene can help in selecting chemotherapeutic drugs and predicting the prognoses of patients.