Comparison of immune responses to a killed bivalent whole cell oral cholera vaccine between endemic and less endemic settings |
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| Authors: | Sachin N. Desai Zenebe Akalu Mekonnen Teferi Byomkesh Manna Samuel Teshome Ju Yeon Park Jae Seung Yang Deok Ryun Kim Suman Kanungo Laura Digilio |
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| Affiliation: | 1. International Vaccine Institute, Seoul, Korea;2. Armauer Hansen Research Institute, Addis Ababa, Ethiopia;3. National Institute of Cholera and Enteric Diseases, Kolkata, India |
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| Abstract: | Studies on safety, immunogenicity and efficacy of the killed, bivalent whole cell oral cholera vaccine (Shanchol) have been conducted in historically endemic settings of Asia. Recent cholera vaccination campaigns in Haiti and Guinea have also demonstrated favourable immunogenicity and effectiveness in nonendemic outbreak settings. We performed a secondary analysis, comparing immune responses of Shanchol from two randomised controlled trials performed in an endemic and a less endemic area (Addis Ababa) during a nonoutbreak setting. While Shanchol may offer some degree of immediate protection in primed populations living in cholera endemic areas, as well as being highly immunogenic in less endemic settings, understanding the characteristics of immune responses in each of these areas is vital in determining ideal dosing strategies that offer the greatest public health impact to populations from areas with varying degrees of cholera endemicity. |
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| Keywords: | oral cholera vaccine cholera immunogenicity vaccin oral contre le cholé ra cholé ra immunogé nicité vacuna oral para el có lera có lera inmunogenicidad |
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