Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome |
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| Authors: | V. DESCAMPS,F. BOUSCARAT,S. LAGLENNE,E. ASLANGUL,B. VEBER,D. DESCAMPS,&dagger ,J-L. SARAUX,&Dagger ,M.J. GRANGE,§ ,M. GROSSIN,¶ ,E. NAVRATIL,,B. CRICKX,S. BELAICH |
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| Affiliation: | Service de dermatologie, Hôpital Bichat, Paris, France;Clinique de réanimation des maladies infectieuses, Hôpital Bichat, Paris, France;Service de virologie, Hôpital Bichat, Paris, France;Service de médecine interne, Centre hospitalier Emile Roux, Euabonne, France;Laboratoire d'hématologie, Hôpital Bichat, Paris, France;Service d'anatomopathologie, Hôpital Bichat, Paris, France;Service d'anatomopathologie, Hôpital Beaujon, Clichy, France |
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| Abstract: | Viral infections are thought to play a part in some cutaneous drug reactions. Human herpesvirus 6 (HHV6), which is the agent of exanthema subitum (sixth disease), has never been implicated in a drug reaction. We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection. We discuss the possible role of HHV6 in this reactive condition. |
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