In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain |
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Authors: | Carles Majós Carles Aguilera Mònica Cos Àngels Camins Ana P. Candiota Teresa Delgado-Goñi Àlex Samitier Sara Castañer Juan J. Sánchez David Mato Juan J. Acebes Carles Arús |
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Affiliation: | 1. Institut de Diagnòstic per la Imatge (IDI). Centre Bellvitge, Hospital Universitari de Bellvitge, Autovia de Castelldefels km 2.7, 08907, L’Hospitalet de Llobregat, Barcelona, Spain 2. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 08193, Cerdanyola del Vallès, Spain 3. Department de Bioquímica i Biologia Molecular, Unitat de Bioquímica de Biociències, Edifici Cs, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallés, Spain 4. Department of Neurosurgery, Hospital Universitari de Bellvitge, C/ Feixa Llarga s/n, 08907, L’Hospitalet de Llobregat, Barcelona, Spain
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Abstract: | The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p < 0.001 and p < 0.01, respectively), high mobile lipids in metastasis (p < 0.001), high Cho in PNET (p < 0.001), high mI + Gly in ependymoma (p < 0.001), high NAC (p < 0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors. Grants: This work was funded in part by MEDIVO2 (MEC SAF2005–03650), and Generalitat de Catalunya SGR2005–00863 and XT2004–51. CIBER-BBN is an initiative of “Instituto de Salud Carlos III” (ISCiii) of Spain. |
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Keywords: | Brain neoplasms Magnetic resonance spectroscopy Intraventricular tumours |
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