原发性高血压患者缺血性脑血管病与颈动脉粥样硬化及碱性成纤维细胞生长因子的关系

目的探讨原发性高血压患者缺血性脑血管病与颈动脉粥样硬化及碱性成纤维细胞生长因子之间的关系及临床意义。方法采用惠普彩色多普勒仪测定颈动脉,观察颈总动脉、颈内动脉和颈动脉分叉部的图像。采用酶联免疫吸附试验方法测定外周血中碱性成纤维细胞生长因子。结果与高血压不伴缺血性脑血管病组比,高血压伴缺血性脑血管病组碱性成纤维细胞生长因子水平(364.5±91.0mg/L比283.4±91.2mg/L)、软斑检出率(92.3%比52.4%)和右侧颈内动脉收缩期峰值流速(57.65±7.34mm/s比52.41±7.97mm/s)均显著升高(P<0.05或0.01);软斑组碱性成纤维细胞生长因子水平比硬斑组明显升高(319.7±93.6mg/L比252.2±77.9mg/L,P<0.05)。结论碱性成纤维细胞生长因子和动脉粥样硬化斑块的形成在高血压缺血性脑血管病的发生发展过程中起重要作用,对判别高血压病变的程度、预防脑梗死提供了重要依据,有利于临床采取正确的干预治疗措施。

Relationship Between Basic Fibroblast Growth Factor, Carotid Artery Atheroscleorsis and Cerebral Ischemic in Patients of Essential Hypertension

Aim To evaluate the relationship between basic fibroblast growth factor (bFGF), carotid artery atheroscleorsis and cerebral ischemicin patients of essential hypertension. Methods B-mode ultrasound examination of common carotid artery (CCA) and internal carotid artery (ICA), bifurcation of carotid artery (BIF) was used. bFGF was measured by enzyme linked immunosorbent assay (ELISA) methods. Results The levels of bFGF (364.5±91.0 mg/L vs 283.4±91.2 mg/L), the incidents of soft plaques (92.3% vs 52.4%) and the peak of blood flow in stage with systole of right internal carotid artery (57.65±7.34 mm/s vs 52.41±7.97 mm/s) increased in patients of essential hypertension with cerebral ischemic group than those in patients of essential hypertension without cerebral ischemic group (P<0.05 or 0.01). The levels of bFGF in soft plaques group increased than that in flat plaques group (P<0.05). Conclusion Levels of bFGF and forming atherosclerosis may be an important factor during the development and discovery of cerebral ischemia, providing important basis for distingusihing the degree of desease with essential hypertension and preventing cerbral infarction, which contributes to intervene treatment.