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Beneficial effects of colchicine in experimental nephrotoxic serum nephritis in the rat
Authors:S. PENCHAS  I. CHARUZI  J. H. BOSS
Affiliation:Departments of Medicine A and Surgery A, Hebrew University Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel
Abstract:Abstract. Glomerulonephritis was induced in rats by multiple injections of rabbit anti-rat kidney serum. Colchicine was administered daily for 4 months to nephrotoxic serum treated rats and untreated control animals. Nephritic rats receiving colchicine had significantly less proteinuria and less glomerular damage than unprotected nephritic animals. A possible role for colchicine in the early treatment of human glomerulonephritis is suggested.
Keywords:Colchicine    anti-inflammatory drugs    experimental glomerulonephritis    nephrotoxic serum
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