Beneficial effects of colchicine in experimental nephrotoxic serum nephritis in the rat |
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Authors: | S. PENCHAS I. CHARUZI J. H. BOSS |
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Affiliation: | Departments of Medicine A and Surgery A, Hebrew University Hadassah Medical School and Hadassah University Hospital, Jerusalem, Israel |
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Abstract: | Abstract. Glomerulonephritis was induced in rats by multiple injections of rabbit anti-rat kidney serum. Colchicine was administered daily for 4 months to nephrotoxic serum treated rats and untreated control animals. Nephritic rats receiving colchicine had significantly less proteinuria and less glomerular damage than unprotected nephritic animals. A possible role for colchicine in the early treatment of human glomerulonephritis is suggested. |
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Keywords: | Colchicine anti-inflammatory drugs experimental glomerulonephritis nephrotoxic serum |
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