Pneumococcal bacteremia in patients with neoplastic diseases |
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| Affiliation: | 1. Department of Emergency Medicine, China Medical University Hospital, Taichung, Taiwan;2. School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;3. Department of Laboratory Medicine, China Medical University Hospital, Taichung, Taiwan;4. Department of Laboratory, Wei-Gong Memorial Hospital, Miaoli City, Taiwan;5. Department of Laboratory, An-Nan Hospital, China Medical University, Tainan, Taiwan;6. School of Medicine, Chang Gung University, Taoyuan, Taiwan;7. Department of Public Health, China Medical University, Taichung, Taiwan;8. Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan;9. Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan;1. Department of Microbiology, Immunology, and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel;2. Department of Electrical and Electronics Engineering, ACLP-Afeka Center for Language Processing, Afeka Tel-Aviv Academic College of Engineering, Tel-Aviv 69107, Israel;3. Department of Physics, SCE - Shamoon College of Engineering, Beer-Sheva 84100, Israel;1. Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel;2. Department of Biology, Science and Technology College, Hebron University, Hebron P760, Palestine;3. Infectious Disease Institute, Soroka University Medical Center, Beer-Sheva, Israel;4. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel;5. Department of Electrical and Electronics Engineering, ACLP-Afeka Center for Language Processing, Afeka Tel-Aviv Academic College of Engineering, Tel-Aviv 69107, Israel;6. LIA Avignon Université, 339 Chemin des Meinajaries, 84000 Avignon, France;7. Department of Physics, SCE - Shamoon College of Engineering, Beer-Sheva 84100, Israel |
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| Abstract: | To evaluate the morbidity and mortality of pneumococcal bacteremia in patients with cancer, we reviewed the 36 case records of patients with one or more blood cultures positive for pneumococci, observed over a 6-year period at the Institut Jules Bordet. The most frequent underlying neoplasms were lung cancer (25%), chronic lymphocytic leukemia and multiple myeloma (25%). In 80% of the patients, the respiratory tract was the source of the infection. A bacteriological clue for pneumococcal infection was available in 21 patients at the onset of bacteremia; pneumococci were seen on Gram-stained smears in 52% and grown in culture in 76% of all the patients. Most patients (33/36) received adequate empirical treatment as soon as the infection was clinically suspected. Nevertheless, the overall mortality during the week following the infection was 42%; 10 of these deaths could be directly attributed to the pneumococcal infection and occurred during the first 3 days after its onset. Among these 10 patients, 8 had been appropriately treated. |
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