The Collagenous Exocytoskeleton of Smooth Muscle Cells |
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| Affiliation: | 1. Division of Clinical Immunology and Rheumatology, Department of Medicine, University Medical Center, Birmingham, Alabama 35294, USA;2. Institute of Dental Research;3. Department of Biochemistry, University of Alabama in Birmingham, Birmingham, Alabama 35294, USA;4. Department of Pathology, The Hahneman Medical College, Philadelphia, Pennsylvania 19102, USA;1. Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland;2. Nordic Bioscience, Fibrosis Biology and Biomarkers, Herlev, Denmark;3. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy;4. Internal Medicine Department, Respiratory Unit and Adult Cystic Fibrosis Center, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milan, Milan, Italy;5. Clinic of Pneumology and Pulmonary Cell Research, University Hospital Basel, Basel, Switzerland;6. Department of Pneumology, Medisch Centrum Alkmaar, Alkmaar, The Netherlands;7. Department of Pneumology, CHU Liege, University of Liege, GIGAI Research Group, Liege, Belgium;8. Department of Pneumology, Institute for Pulmonary Diseases, Belgrade, Serbia;9. Department of Pneumology, Amphia Hospital/Erasmus MC, Breda, The Netherlands;10. Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht the Netherlands;11. Microbiology Department, Hospital Universitari Germans Trias I Pujol, Badalona Universitat Autonoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III, Barcelona Spain;12. Pneumology, Hospital Clinic, Barcelona Spain;13. Pneumology Medizinische Hochschule, Hannover Germany;1. Division of Neonatology and Pediatric Molecular and Personalized Medicine Program, Department of Pediatrics, University of Rochester, Rochester, New York;2. Department of Biomedical Genetics, University of Rochester, Rochester, New York;3. Center for Mitochondrial and Epigenomic Medicine, Children''s Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania;4. Department of Molecular Medicine, University of Padova, Padova, Italy |
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| Abstract: | Using specific antibodies in immunoelectron microscope studies with vascular tissues, type V collagen has been localized in basement membrane structures associated with discrete regions of the smooth muscle cell surface as well as membranous structures adjacent to endothelial cell membranes. These results confirm and extend earlier light microscope observations suggesting that type V collagen is largely associated with the pericellular environment in such tissues. |
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