环氧合酶-2在食管鳞癌组织中的表达及意义

目的探讨环氧合酶-2（COX-2）在食管鳞癌发生及其转移中的作用、意义。方法采用免疫组化方法检测19例食管正常黏膜、15例不典型增生食管组织及45例食管鳞癌组织中COX-2的表达。结果正常食管黏膜组织中COX-2不表达，轻中度、重度不典型增生组织及食管鳞癌组织中COX-2的阳性表达率分别为1／8、3／7和28／45，依次增加（P〈0．05）。不同分化程度和浸润深度的食管鳞癌组织中，COX-2阳性表达率差异无统计学意义（P〉0．05），但有淋巴结转组织COX-2的阳性表达率（80．95％）高于无淋巴结转移组的阳性表达率（45．83％）（P〈0．05）。结论COX-2表达可能是食管癌发生过程中的早期事件，与淋巴结转移密切相关，与肿瘤分化程度及浸润深度无关．COX-2可以作为判断病情和评价预后的指标。

The Expression of COX-2 Protein in Esophageal Squamous cell Carcinoma

Objective To study the expression of COX-2 in esophageal squamous cell carcinoma. Methods The expression of COX-2 was examined using immunohistochemieal staining in 19 cases of mormal mucosa, 15 cases of dysplasia bi- opsy and 45 cases of esophageal squamous cell carcinoma samples. Results The positive rates of COX-2 in mormal esophageal mucosa mild dysplasia, severe dysplasia and esophageal squamous cell carcinoma were 0, 1/8, 3/7, and 28/45, respectively which increased consequently （ P 〈 O. 05 ） . Among different differentiated grade and invasive depth carcinoma tissue, there were no significant differences in the positive rates of COX-2 （ P 〈 0. 05 ）, but in the groups with and without lymph node metastases, the rates were 80. 95% and 45. 85% respectively, the differences was significant （ P 〈 0. 05 ） . Conclusion Expression of COX-2 maybe play a role at the early phase of carcinogenesis and maybe related with lymph node metastasis, but not with the differentiated grade and invasive depth of the tumor, it maybe identified as a definite diagnositc and evaluating prognostic markers.