迭代二步法估算维拉帕米的群体药动学参数

目的 :为临床合理应用维拉帕米提供依据。方法 :53例高血压患者口服维拉帕米片 ,采用荧光分光光度法测定血浆中维拉帕米浓度 ,用迭代二步法估算维拉帕米的群体药动学参数 ,并与传统二步法的结果比较。结果 :迭代二步法估算维拉帕米的CL为(189 3±59 3)ml/(h·kg) ,Vd 为 (1 420±0 231)L/kg ,T1/2 为 (5 74±1 90)h ,与传统二步法拟合的结果基本一致。结论 :迭代二步法能较好地估算出维拉帕米的群体及个体药动学参数 ,可用于预测血药浓度及优化个体给药方案。

Estimating Population Pharmacokinetic Parameters of Verapamil by Iterative Two Stage Method

OBJECTIVE:To provide basis for rational use of verapamil in clinical practice.METHODS:53 patients with hypertension received oral verapamil.The concentrations of verapamil in plasma were determined by fluorespectrophotometry.The population pharmacokinetic parameters were estimated by iterative two stage method and compared with the results estimated by traditional standard two stage method.RESULTS:The population pharmacokinetic parameters in 53 patients were,CL(189.3±59.3)ml/(h·kg),Vd(1.420±0.231)L/kg,T1/2(5.74±190)h,the parameters had no significant difference as compared with the parameters estimated by traditional standard two stage method.CONCLUSION:Iterative two stage method is suitable for estimating population pharmacokinetic parameters,forecasting plasma concentration and optimizing individualized dosage regimen.