血清hs—CRP及CA125对子宫内膜异位症患者诊断价值的研究

目的探讨血清超敏C反应蛋白（high sensitivity C-reactive protein，hs—CRP）和125检测用于诊断子宫内膜异位症（endometriosis，EM）的临床价值。方法选择24例无EM患者（对照组）为A组．46例EM患者为B组．并根据r-AFS分期法将B组患者分为BⅠ／Ⅱ组28例和BⅢ／Ⅳ组18例。采用免疫比浊法和电化学发光法检测各组患者血清hs—CRP和125水平，对数据进行统计学分析，并评价这两项指标单独及联合检测对EM的诊断价值。结果B组患者血清hs—CRP和125水平和阳性率均明显高于A组，BⅢ／Ⅳ组均明显高于BⅠ／Ⅱ组，差异均有统计学意义（P均〈0．05）。hs—CRP和125联合检测阳性率，B组高于A组，BⅢ／Ⅳ组高于BⅠ／Ⅱ组，差异均有统计学意义（P均〈0．05）。hs—CRP单项检测的诊断特异性（83.33％）低于125（91．67％），而灵敏度（67．39％）高于125（56．52％）。联合检测时，特异性和阳性预测值为100．00％，但灵敏度较低（54．35％）。结论血清hs—CRP对EM的诊断灵敏度优于125，与125联合检测有助于提高EM的诊断准确性。

A study on the diagnostic value of testing serum hs-CRP and CA125 levels in endometriosis patients

Objective To investigate the clinical value of testing serum high sensitivity C-reactive protein（hs-CRP） and CA125 for endometriosis（EM） diagnosis. Methods 24 cases patients without EM（control group） as A group, and 46 cases patients with EM （B group） were selected. B group was divided into B Ⅰ / Ⅱ group （28 cases） and BⅢ/Ⅳ group （18 cases） by r-AFS method. Levels of serum hs-CRP and CA125 were detected by immunoturbidimetry and eleetroehemiiumineseene immunoassay. The datas were analyzed by statistical method, and the diagnosis values of hs-CRP and CA125 in single and combined detection were evaluated. Results Levels and positive rates of serum hs-CRP and CA125 in B group were higher than in A group, and in B Ⅲ/Ⅳ group were higher than in B Ⅰ /Ⅱ group, and the differences all had statistical significance （Pall〈 0.05）. The positive rate of combined detection in B group was higher than in A group, and in B Ⅲ/Ⅳ group was higher than in B Ⅰ /Ⅱ group, and the differences all had statistical significance（Pall〈 0.05）. In single detection, diagnostic specificity of hs-CRP （83.33%） was lower than CA125 （91.67%）, and sensitivity （67.39%） was higher than CA125 （56.52%）. In combined detection, the specificity and positive predictive value were all 100.00%, but sensitivity was low （54.35%）. Conclusion The diagnostic sensitivity of hs-CRP on EM is superior than that of CA 125, and a test of both can help improve the diagnosis accuracy.