水飞蓟素抗肿瘤作用及其机制研究进展

水飞蓟素是从植物水飞蓟种子中提取得到的一类生物活性成分,含65%～80%黄酮木脂素(或称水飞蓟素混合物)、少许黄酮、20%～35%脂肪酸和一些多酚。水飞蓟素除用于治疗肝炎和肝硬化等肝脏疾病外,对前列腺癌、皮肤癌、膀胱癌、肺癌和结肠癌等具有抑制作用。近年研究发现,水飞蓟素抗肿瘤的作用机制与其调节细胞周期、诱导细胞凋亡及抑制新生血管形成等作用有关。另外,水飞蓟素具有抗炎、抗肿瘤转移及抗氧化活性,与抗肿瘤药物具有协同增效作用。

Progress in antineoplastic effects and mechanisms of silymarin

Silymarin is a kind of active extract from the seeds of the plant Silybum marianum, and it contains 65%-80% silymarin flavonoligans (silymarin complex) with small amounts of flavonoids, 20%-35% fatty acids and other polyphenolic compounds. These ingredients have been used to protect against liver diseases such as hepatitis and cirrhosis in clinical for many years. Silymarin and silybin also exhibited versatile antineoplastic effects, such as prostate cancer, skin cancer, urinary bladder cancer, lung cancer, colon cancer, and so on. It was reported that the mechanisms of silymarin and silybin underlying antineoplastic activities are related with cell cycle regulation, apoptosis induction and antiangiogenic activity. They also have anti-inflammatory effect, anti-metastatic activity and antioxidant activity. In addition, they have the cooperating and intensifying actions on the curative effect of cytotoxic chemo-agents.